Utilization of Observational Data as a Proxy Cohort for Comparison Purposes with Open-Label Study Results: An Example from Alzheimer’s Disease

Randomized placebo-controlled trials in the development of disease-modifying treatments for Alzheimer’s disease are typically of short duration (12–18 months), and health economic modeling requires extrapolation of treatment effects beyond the trial period.

(1) Reed, C., Happich, M., Raskin, J. et al. J Prev Alzheimers Dis (2019) 6: 90–99 https://doi.org/10.14283/jpad.2019.4

Article