It is well established that the immune response decreases with aging. With this, we observe a moderate increase in circulating inflammatory mediators, known as “inflamm-aging”. However, the dynamics of the immune loss process, at the individual level, has not been… Continue Reading →
The Contents of the Journal of Frailty & Aging (JFA) vol. 8, n° 2, 2019 are available Biology of Frailty The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer’s Disease: A novel… Continue Reading →
With age, human tissues are less able to regenerate and age-related diseases appear. A cell becomes senescent when the damage exposition persists. The cell is then exposed to prolonged stress; and by a mechanism independent of p16Ink4a and p21Cip2, irreversible… Continue Reading →
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